Death Receptors and Cognate Ligands in Cancer

This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development. Death receptors play a central role in directing apoptosis in mammalian cells.

Death Receptors and Cognate Ligands in Cancer

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.

More Books:

Death Receptors and Cognate Ligands in Cancer
Language: en
Pages: 280
Authors: Holger Kalthoff
Categories: Medical
Type: BOOK - Published: 2010-03-12 - Publisher: Springer Science & Business Media

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many
Death Receptors and Cognate Ligands in Cancer
Language: en
Pages: 280
Authors: Holger Kalthoff
Categories: Medical
Type: BOOK - Published: 2009-10-06 - Publisher: Springer

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many
Death Receptors in Cancer Therapy
Language: en
Pages: 374
Authors: Wafik S. El-Deiry
Categories: Medical
Type: BOOK - Published: 2007-11-15 - Publisher: Springer Science & Business Media

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their
Combined Impact of the Proteasome Inhibitor Bortezomib and Ex Vivo-activated Natural Killer Cells on Human Glioma Stem Cell Targeting and Cytotoxicity
Language: en
Pages: 58
Authors: Ian Sturgill
Categories: Medical
Type: BOOK - Published: 2017 - Publisher:

Of all of the types of primary brain tumors, glioblastoma multiforme (GBM) is both the most common and most aggressive. As a direct result of its aggressiveness and its location within sensitive brain tissue beyond the blood-brain barrier, successful treatment is a significant challenge and mortality is high, even when
TRAIL, Fas Ligand, TNF and TLR3 in Cancer
Language: en
Pages: 317
Authors: Olivier Micheau
Categories: Medical
Type: BOOK - Published: 2017-07-03 - Publisher: Springer

This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic