Death Receptors in Cancer Therapy

In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for ...

Death Receptors in Cancer Therapy

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

More Books:

Death Receptors in Cancer Therapy
Language: en
Pages: 374
Authors: Wafik S. El-Deiry
Categories: Medical
Type: BOOK - Published: 2007-11-15 - Publisher: Springer Science & Business Media

An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their
Development and Biological Characterization of Synthetic Molecules Targeting Death Receptor 5
Language: en
Pages: 222
Authors: Julien Beyrath
Categories: Medical
Type: BOOK - Published: 2010 - Publisher:

Evasion of apoptosis is one of the major hallmarks of cancer. Apoptosis is a physiologic mechanism leading to cell death involved in the clearance of cancer cells. Apoptosis can be triggered extracellularly by pro-apoptotic receptor agonists (PARAs), belonging to the tumor necrosis factor (TNF) family, activating the "extrinsic" pathway. Among
Death Receptors and Cognate Ligands in Cancer
Language: en
Pages: 280
Authors: Holger Kalthoff
Categories: Medical
Type: BOOK - Published: 2010-03-12 - Publisher: Springer Science & Business Media

Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many
Programmed Cell Death in Cancer Progression and Therapy
Language: en
Pages: 356
Authors: Roya Khosravi-Far, Eileen White
Categories: Medical
Type: BOOK - Published: 2007-12-29 - Publisher: Springer Science & Business Media

Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters
TRAIL, Fas Ligand, TNF and TLR3 in Cancer
Language: en
Pages: 317
Authors: Olivier Micheau
Categories: Medical
Type: BOOK - Published: 2017-07-03 - Publisher: Springer

This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic