In Death Receptors in Cancer Therapy, leading physician-scientists and basic researchers review in depth our latest understanding of the molecular events that regulate cell death, illuminating those molecules that provide targets for ...
More Books:
Language: en
Pages: 374
Pages: 374
An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their
Language: en
Pages: 222
Pages: 222
Evasion of apoptosis is one of the major hallmarks of cancer. Apoptosis is a physiologic mechanism leading to cell death involved in the clearance of cancer cells. Apoptosis can be triggered extracellularly by pro-apoptotic receptor agonists (PARAs), belonging to the tumor necrosis factor (TNF) family, activating the "extrinsic" pathway. Among
Language: en
Pages: 280
Pages: 280
Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many
Language: en
Pages: 356
Pages: 356
Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters
Language: en
Pages: 317
Pages: 317
This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic