Genetic Instability and Tumorigenesis

M. B. KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells.

Genetic Instability and Tumorigenesis

M. B. KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast, in the majority of cancers, no such inherited gene abnormalities can be identified (which does not mean that they do not exist) and there is no obvious family history suggesting an inherited disease. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual. Thus, the critical question which arises is "how do these genetic changes occur in somatic cells?". Epidemiologic data suggest that exposure to environmental carcinogens con tributes to the genesis of at least 80% of all human cancers (DOLL and PETO 1981). Thus, it is natural to suspect that the genetic changes in somatic cells which con tribute to the transformed phenotype arise from DNA damage caused by such exposures. Therefore, understanding how cells respond to DNA-damaging agents is likely to be an important component of our understanding of the genesis of human tumors.

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Genetic Instability and Tumorigenesis
Language: en
Pages: 180
Authors: Michael B. Kastan
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

M. B. KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast,
Cancer: Cell Structures, Carcinogens and Genomic Instability
Language: en
Pages: 376
Authors: Leon P. Bignold
Categories: Medical
Type: BOOK - Published: 2006-01-27 - Publisher: Springer Science & Business Media

This volume began with an invitation from the publishers to edit a volume of EXS on Cancer. This invitation undoubtedly derived from my articles in Cellular and Molecular Life Sciences in 2002 and 2003 on the relationships between the morphology, aetiology and pathogenesis of tumours, especially in relation to genetic
Genetic Instability and Tumorigenesis
Language: en
Pages: 196
Authors: Michael B Kastan
Categories: Medical
Type: BOOK - Published: 1996-11-12 - Publisher:

Books about Genetic Instability and Tumorigenesis
Genome and Disease
Language: en
Pages: 246
Authors: Jean-Nicolas Volff
Categories: Medical
Type: BOOK - Published: 2006-01-01 - Publisher: Karger Medical and Scientific Publishers

Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human
Checkpoint Kinase-Dependent Regulation of DNA Repair and Genome Instability in Breast Cancer
Language: en
Pages: 29
Authors: Jean-Nicolas Volff
Categories: Medical
Type: BOOK - Published: 2009 - Publisher:

The DNA damage response (DDR) functions as a tumorigenesis barrier. It is activated in precancerous lesions, potentially as a consequence of aberrant DNA replication. The genetic alterations that create this genomic instability are poorly defined. Using a functional genomic screen in human cells we identified seventy-four genes that when silenced