Preoperative Neoadjuvant Chemotherapy

Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance.

Preoperative  Neoadjuvant  Chemotherapy

Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.

More Books:

Preoperative (Neoadjuvant) Chemotherapy
Language: en
Pages: 162
Authors: Joseph Ragaz, Pierre R. Band, James H. Goldie
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing
Neoadjuvant Chemotherapy
Language: en
Pages: 114
Authors: Maurie Markman
Categories: Medical
Type: BOOK - Published: 2013-05-22 - Publisher: BoD – Books on Demand

In the chapters of this excellent text, the authors have described advances in the neoadjuvant chemotherapeutic management of a number of tumor types. Based on the extensive experience with this management concept in breast cancer, several chapters are devoted to this important topic (Section 1). Section 2 deals with the
Neoadjuvant Chemotherapy
Language: en
Pages: 270
Authors: Oliver Bathe
Categories: Medical
Type: BOOK - Published: 2012-02-01 - Publisher: BoD – Books on Demand

The most significant advances in cancer therapy in recent years have involved the development of systemic therapeutics. With improvements in response rates in solid tumors, opportunities have arisen to enhance the effectiveness of surgery. Administration of systemic therapy prior to surgery - neoadjuvant chemotherapy - represents one approach by which
The Role of Neoadjuvant Chemotherapy in Patients with High-grade Neuroendocrine Carcinoma of the Uterine Cervix
Language: en
Pages:
Authors: Dae-Yeon KIm
Categories: Medical
Type: BOOK - Published: 2017 - Publisher:

Objective We evaluate the feasibility and efficacy of neoadjuvant chemotherapy in the management of patients with high-grade neuroendocrine(HGNE) carcinoma of the uterine cervix using a matched case-control studyMethodology We performed a single-center, retrospective study of 58 surgically treated HGNE cervical cancer patients. Of these patients, 13 patients (20.90%) received neoadjuvant
Breast Surgery
Language: en
Pages: 158
Authors: W. G. Cance
Categories: Medical
Type: BOOK - Published: 2001 - Publisher: IOS Press

The volume provides a comprehensive review of the surgical aspects of breast disease from the leaders in their fields. Each chapter offers a discussion of a certain topic or field along with the author's assessment of future directions. The topics range from the surgical management of high risk patients, a