Radiation Carcinogenesis and DNA Alterations

This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October 1984 in Corfu, Greece.

Radiation Carcinogenesis and DNA Alterations

This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October 1984 in Corfu, Greece. The meeting received finan cial support from the United States Department of Energy and the United States National Cancer Institute. A plethora of recent developments in the molecular biology of DNA are leading to new ideas concerning how DNA alterations might be involved in the mechanism of radiation carcinogenesis. Evidence is accumulating that genetic sequences, known as oncogenes, are involved in the translation of DNA molecular alterations into phenotypic changes associated with malignant cells. For example, a chromosome break often occurs at or near the loca tion of a specific oncogene in Burkitt's lymphoma. Such breaks could represent initial lesions in a translocation process that activates the oncogene by inserting it at a new location, eg., near an active pro moter. Since breakage of the DNA is one of the principal ways that ion izing radiation affects mammalian cells, these new molecular ideas sug gest ways that radiation-induced DNA breaks might be involved as initial events in carcinogenesis. While the possible involvement of oncogenes in radiation carcino genesis is an exciting new development, a direct sequential connection between early molecular changes in DNA and later tumor development has yet to be established. Accordingly, there is a tremendous need for experimental studies of how DNA alterations might convert normal cells to cancer cells.

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Radiation Carcinogenesis and DNA Alterations
Language: en
Pages: 618
Authors: Frederic J. Burns
Categories: Medical
Type: BOOK - Published: 2013-03-13 - Publisher: Springer Science & Business Media

This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October 1984 in Corfu, Greece. The meeting received finan cial support from the United States Department of Energy and the United States National Cancer Institute. A plethora of
Radiation Carcinogenesis and DNA Alterations
Language: en
Pages: 636
Authors: Frederic J Burns
Categories: Medical
Type: BOOK - Published: 1987-05-01 - Publisher:

Books about Radiation Carcinogenesis and DNA Alterations
Mechanisms of DNA Damage and Repair
Language: en
Pages: 578
Authors: Michael G. Simic, Lawrence Grossman, Arthur C. Upton, David S. Bergtold
Categories: Science
Type: BOOK - Published: 2013-11-21 - Publisher: Springer Science & Business Media

This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level;
Aging, Carcinogenesis, and Radiation Biology
Language: en
Pages: 561
Authors: Kendric Smith
Categories: Medical
Type: BOOK - Published: 2013-03-09 - Publisher: Springer Science & Business Media

The covalent attachment to deoxyribonucleic acid in vivo of a large number of different types of chemical compounds (both normal cellular constituents such as proteins and amino acids, and also exogenous compounds such as drugs, carcinogens, etc. ) have been shown to exert profound effects upon cells. Four research activi
Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell
Language: en
Pages: 79
Authors: Yoshimasa Saito
Categories: Biology (General)
Type: BOOK - Published: 2014-11-10 - Publisher: Frontiers E-books

Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine