The Hereditary Basis of Childhood Cancer

This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers.

The Hereditary Basis of Childhood Cancer

This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the ‘disease-related’ chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical manifestations, to relate the relationship of the molecular oncologic pathways with relevant developmental or non-human species biology in order to better understand the complexity of these systems. The resulting clinical implications of understanding this biology are elaborated on. Chapters 13-16 discuss the broader psychosocial, ethical and genetic counseling issues that arise and that are so critical to translating the knowledge gained from advances in molecular genetics into the clinic. Chapter 12 in particular provides a unique perspective of the application of this knowledge in less-developed nations where ‘modern’ technologies may not be readily available, but where the clinical manifestations of these disorders are prevalent.

More Books:

The Hereditary Basis of Childhood Cancer
Language: en
Pages: 491
Authors: David Malkin
Categories: Medical
Type: BOOK - Published: 2021-09-07 - Publisher: Springer

This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the ‘disease-related’ chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical
The Hereditary Basis of Childhood Cancer
Language: en
Pages: 491
Authors: David Malkin
Categories: Medical
Type: BOOK - Published: 2021-09-06 - Publisher: Springer Nature

This volume elaborates on the research and clinical implications of the hereditary and molecular basis of childhood cancers. The focus of the ‘disease-related’ chapters of the book is to integrate what is known about the molecular basis of that particular clinical entity (or group of related entities) with the clinical
The Genetic Basis of Common Diseases
Language: en
Pages: 1096
Authors: Richard A. King, Jerome I. Rotter, Arno G. Motulsky
Categories: Medical
Type: BOOK - Published: 2002-10-17 - Publisher: Oxford University Press

Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition
The Genetic Basis of Haematological Cancers
Language: en
Pages: 384
Authors: Sabrina Tosi, Alistair G. Reid
Categories: Science
Type: BOOK - Published: 2016-03-02 - Publisher: John Wiley & Sons

Written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. Focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is
Cancer Genomics
Language: en
Pages: 510
Authors: David Malkin
Categories: Medical
Type: BOOK - Published: 2013-11-21 - Publisher: Elsevier Inc. Chapters

Cancer is the most common cause of disease-related death in children beyond the newborn period. Most cancers are thought to arise sporadically; however, classical studies of well-defined familial cancer associations, known as cancer predisposition syndromes (CPS), together with emerging work arising from new high-resolution genomic platforms have confirmed that at